The Fourth Quadrant: a Map of the Limits of Statistics

Statistical and applied probabilistic knowledge is the core of knowledge; statistics is what tells you if something is true, false, or merely anecdotal; it is the “logic of science”; it is the instrument of risk-taking; it is the applied tools of epistemology; you can’t be a modern intellectual and not think probabilistically—but… let’s not be suckers. The problem is much more complicated than it seems to the casual, mechanistic user who picked it up in graduate school. Statistics can fool you. In fact it is fooling your government right now. It can even bankrupt the system (let’s face it: use of probabilistic methods for the estimation of risks did just blow up the banking system).

Link to essay – www.edge.org/conversation/the-fourth-quadrant-a-map-of-the-limits-of-statistics

[Twitter | X] Nassim Nicholas Taleb on the Kelly Criterion and Mutual Information in Investment Settings

[Twitter | X] Nassim Nicholas Taleb Cites JAMA Study to Reinforce Critique of Statistical Gerrymandering in Drug Recommendations

Link to JAMA study: jamanetwork.com/journals/jamanetworkopen/fullarticle/2821340

[Twitter/X] Nassim Nicholas Taleb Explains the Research Surge in Developing Countries

Paper: Anatolian genetic ancestry in North Lebanese populations

Lebanon’s rich history as a cultural crossroad spanning millennia has significantly impacted the genetic composition of its population through successive waves of migration and conquests from surrounding regions. Within modern-day Lebanon, the Koura district stands out with its unique cultural foundations, primarily characterized by a notably high concentration of Greek Orthodox Christians compared to the rest of the country. This study investigates whether the prevalence of Greek Orthodoxy in Koura can be attributed to modern Greek heritage or continuous blending resulting from the ongoing influx of refugees and trade interactions with Greece and Anatolia. We analyzed both ancient and modern DNA data from various populations in the region which could have played a role in shaping the current population of Koura using our own and published data. Our findings indicate that the genetic influence stemming directly from modern Greek immigration into the area appears to be limited. While the historical presence of Greek colonies has left its mark on the region’s past, the distinctive character of Koura seems to have been primarily shaped by cultural and political factors, displaying a stronger genetic connection mostly with Anatolia, with affinity to ancient but not modern Greeks.

Link to paper – www.nature.com/articles/s41598-024-66191-x.epdf

A case study in Non-replicability of a Medical paper [YouTube]

A case study in non-replicability of a medical paper. I discuss it with Dr. Fouad Fayad from U.S.J. in Lebanon. Details are in Retraction Watch.

Apparently, the only reply to his case by the study’s lead author is of the fact-free data-free sort “he doesn’t like me” which does not appear to have a statistical explanation.

Note: Retraction Watch did a great job presenting facts, and the attempt to retaliate against Dr. Fayad. Note that the 4 expert reports were not attached. Also, note that the paper violated FDA rules (and those of the corresponding European agency).

[Medium] Foreword to Mark Spitznagel’s book Safe Haven

Santa Marina — Karl Popper — Herman Hesse’s Sidharta — Mutua Muli — Porsche’s no substitute

Santa Marina

In my ancestral village in the Northern Levant, on top of a hill, stands a church dedicated to Santa Marina. Marina is a local saint, though, characteristically, some other traditions claim her –such as Bithynia or other Anatolian provinces of the Eastern Roman Empire.

Read the complete foreword on Medium.

Get the book on Amazon.